Endocrine Abstracts

Purpose: A combined model of clinical, biochemical and radiological variables could help to predict autonomous cortisol secretion (ACS) in adrenal incidentalomas (AI).Methods: We analyzed retrospectively 100 patients diagnosed of AI between 2011 and 2015. AI was defined as an adrenal mass>1 cm, accidentally discovered by radiologic examination. ACS was ruled out (ACS-) by serum cortisol post-dexamethasone suppression test (Nugent) <3 μg/dl, ...

IntroductionEctopic Cushing’s syndrome (ECS) is a rare entity caused by ACTH secretion by a non-pituitary tumor. The management of these patients is challenging due to its low frequency and limited experienced. The objective of this study was to describe the patients with ECS treated in the Division of Endocrinology at the Ramón y Cajal University Hospital (Madrid, Spain) in the last six years.Methods<p class="abstext...

About 10–15% of prolactinomas (P) are resistant to Dopamine agonists (DA). We analyzed retrospectively ten resistant prolactinomas (RP) treated at our center between 1995 and 2014, to identify useful variables to predict DA resistance and its different patterns (biochemical resistance (BR), morphological resistance (MR) or both). BR is defined as the failure to normalize prolactin (PRL) levels with ≥ 2 mg/week of cabergoline (C) for at least 3 months. MR is consider...

Introduction: Current guidelines propose temozolomide (TMZ) as the first-line chemotherapy for aggressive pituitary neuroendocrine tumors (PitNETs), but no clinical trials have been conducted and clinical experience in this context is limited.Patients and methods: A retrospective study of patients with aggressive pitNETs treated with TMZ was conducted by the members of the Neuroendocrinology Working Area of the Spanish Society of Endocrinology and Nutrit...

Introduction: The incidence of papillary thyroid microcarcinomas (MPT, max diameter≤10 mm) has increased in recent years. Most have a very good prognosis but some have growth during follow-up, lymph node and / or distant metastases.Material and methods: We performed a single-center, retrospective cohort study, n=114 patients (86% women, average age 48.3 years), diagnosed with MPT between 1998 and 2012. Risk stratification system (ATA 2015): 10 high...